Assessment of the potential ameliorative role of Origanum vulgare on permethrin-induced toxicity

Origanum vulgare (O. vulgare), is a medicinal plant which is traditionally used to treat different diseases. In this study, we evaluated the potential protective effects of O. vulgare against the toxic effects of permethrin (PM) in rats. Thirty adult rats were orally treated with normal saline as a control group, PM (150 mg/kg) as the second group, and (PM (150 mg/kg) + O. vulgare (300 mg/kg)) as the third group, once a day for 21 consecutive days. After completion of the study, clinical signs and body weight were assessed. Tissues and blood samples were collected for histopathological examination, biochemical alterations, and hematological analysis. The findings of this study demonstrated that PM induced some clinical signs and significantly declined the body weight of the treated rats. The tissue sections of animals in the second group showed some tissue complications in the liver, heart, lung, and kidney. In addition, hematological parameters including WBC, RBC, Hb, HCT, MCV, MCH, PLT, and biochemical parameters including ALT, AST, ALP, BUN, and creatinine were significantly changed. On the other hand, in the third group, O. vulgare reduced hematological, biochemical, and histopathological abnormalities, significantly. Furthermore, this plant could improve clinical signs and body weight changes. In conclusion, our results demonstrated that O. vulgare could be a potential herbal medicine for reducing the toxicity of PM.