The effect of vitamin D supplementation on bone parameters in pregnant women with vitamin D deficiency: A Clinical Trial

Low vitamin D levels has been associated with an increased risk of type 1diabetes mellitus, cardiovascular disease, certain cancers, and also pregnancy complications. Several studies have shown that vitamin D levels in pregnant women are lower than recommended. The aim of this study was to determine the effect of vitamin D supplementation on bone parameters in pregnant women with vitamin D deficiency. 

It was a clinical trial study (before and after).The study population was 41 pregnant women (being at 12–14 weeks of gestation) with vitamin D deficiency. The study duration was six month.The present study had two phases of vitamin D3 supplementation (50000 IU / week for 12 weeks and then 50000 IU / month for three months). Serum Calcium, Phosphorus, magnesium, Alkaline phosphatase  (ALP) , Parathyroid Hormone(PTH) and  25-hydroxyvitamin D (25(OH)D) level were measured three times.

 At the end of 12 weeks(the first stage) and 3 months(the second stage) of supplementation , the mean levels of  vitamin 25OHD increased and PTH decreased significantly (p<0/001). After supplementation Phosphorus, and ALP, increased significantly (p<0/001). At the end of the study serum calcium and magnesium showed no statistically significant differences.

According to the results of this study, vitamin D supplementation (50000 IU / week for 12 weeks)  increased vitamin D levels in pregnant women and produced no adverse effects and all bone parameters were in suitable condition.