Neurodegeneration and Cognition Disorders Due to Aluminum Nanoparticle Occupational Exposure

Epidemiological studies show that long-term exposure to aluminum (Al) nanoparticles in occupational environments leads to cognitive impairment and neurotoxicity. Al is a relatively widespread neurotoxin associated with motor and cognitive disorders and associated with neurological diseases. For many years, Al has been implicated in the etiology of Alzheimer's disease (AD) in the so-called "Al in AD hypothesis". Recently, most studies have described how it plays a role in the onset, aggressive nature, and progression of AD. The toxicity of Al is related to its pro-oxidant activity, which acts through the formation of Al superoxide radical cation. At present, while the role of Al in AD is becoming clearer, the underlying mechanism of toxicity is still not understood. In this study, we investigate the effect of phosphorylated tau and cognitive impairment due to exposure to very fine aluminum particles.