Gastroprotective effect of Iraqi dates Palm (Phoenix dactylifera L. Cv. "Barhi") dates and seeds extracts on ethanol-induced gastric ulcer in rats

The goal is to find effective treatments for gastric ulcers with minimal side effects. We used ethanol-induced gastric ulcer models in rats to examine the gastro-protective benefits of Iraqi dates palm (Phoenix dactyliferaL. Cv. " Barhi ")

Six groups of seven rats each were formed from 42 rats. Groups 1 (normal control) and 2 (negative control) were given 10 ml/kg of distilled water; group 3 (positive control) was given famotidine (20 mg/kg); groups 4 date palm fruit extract were given (8 ml/kg); groups 5 date palm seed extract were given (8 ml/kg); and groups 6 mixture of date palm fruit extractand date palm seed extract were given (8 ml/kg). On day 15, rats in all groups (except the normal control group) received an oral administration of 99.8% ethanol (5 ml/kg) to cause an acute ulcer. All animals were slaughtered after 1 hour, and their stomachs were removed for further analysis.

Date fruit, date seed, and a combination of aqueous extracts were efficient in reducing the severity of gastric ulceration and protecting against ethanol's negative effects on gastrin, glutathione, and gastric mucus.

Date extracts have been hypothesized to have a gastroprotective effect due to their potential anti-oxidant properties.