Oxidative stress state in patients with atopic Eczema in Anbar Governorate

Atopic Eczema commonlyknown as atopic dermatitis(AD), is a form ofinflammatory skin condition that impairs the skin barrierand its capacity toretain moisture, it is the most prevalent chronic skin conditionand is inherited.Although AD can affect people of all ages, it most often first manifests ininfancy and early childhood. (AD) a varied, complexchronic inflammatoryskin condition, Atopic dermatitis is thought to arisefor a variety of reasons, including genetic factors connected to filaggrin malfunction. Both itsduration and its onset in maturity are possibilities, Patients are affected by the intense itching of the disease, which commonly results in skin injuries and major sleep problems, as well as the social shame attached to having a visible skin ailment. Through the activation of genes that codefor proinflammatory cytokines,oxidative stress encourages tissue inflammation. Free radicalsare then released when inflammatory cells are activated. Given AD'sstrong inflammatory underpinning, Since oxidative stress has been shown to have a major role in skin aging, it is likely that it contributes to the genesis of the illness. Researchingthe correlation between oxidative stressors including MDA, SOD, and T-AOC, as well as inflammation, is crucial in Alzheimer's disease.We enrolled 75 patients dividedinto (25 infants, 25 children,and 25 adults)with AD and 51 healthy controls divided into(17 infants, 17 children,and 17 adults) individuals who did not have the disease and had no history of AD. We measure serum (Malondialdehyde MDA, Superoxide dismutase SOD,and Total antioxidant capacity T-AOC).Serum (MDA) levels were significantly increased in ADpatients comparedto controls, and Serum (SOD and T-AOC) levelsweresignificantly decreased in AD patients compared to controls.