Evaluation of alcohol extract of Foeniculum vulgare mill in repair of skin wound in rat

Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of the holistic systems of medicine providing valuable information on natural remedies. Foeniculum vulgare mill has analgesic, healing, antioxidant, and anti-inflammatory properties. This study evaluated the effect of the hydroalcoholic extract of Foeniculum vulgare mill leaves on skin wound repair.Wounds were induced on 60 rats in four groups, control, nitrofurazone treatment, user ointment, and treated with Foeniculum vulgare mill the 10%onitment extract. The treatment was performed daily, until day 21 after wound induction. Wound closure was measured and the features of the repaired tissue were investigated by histopathology in 7, 14, and 21 days after wound induction, including epithelization, inflammation, collagen deposition, angiogenesis, and fibroblasts.The histopathological findings show that the Foeniculum vulgare mill Group and nitrofurazone group have significant differentiation from the control and user groups. Day 7 in collagen and fibroblast factors showed significant differentiation. Day 14 in epithelization factor and day 21 in collagen fibroblast and inflammation factors showed significant differentiation.Therefore, the ability of anti-inflammatory, antioxidative, and antibacterial parameters of the Foeniculum vulgare mill could be suggestible effective for the treatment of wounds.