The effect of 8 weeks of aerobic training on changes in AST, ALT and metabolic indices of postmenopausal women with type 2 diabetes

Liver enzymes are among the clinical biochemical parameters of liver function in muscle training, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes are indicators of liver damage in sports activities. Therefore, this study aimed to investigate the effect of 8 weeks of aerobic training on changes in aspartate aminotransferase, alanine aminotransferase, and metabolic indices in postmenopausal women with type 2 diabetes.

The current research is semi-experimental and was implemented with a pre-test and post-test design. 40 postmenopausal women with type 2 diabetes with an average age of 55-60 years were randomly divided into two groups aerobic exercise (20 people) and control (20 people). The aerobic training program was implemented for 8 weeks, five sessions a week for 60 minutes with an intensity of 50-75% of the reserve heart rate. ALT and AST levels as well as fat profile factors were measured in the pre-test and post-test. The data were analyzed by covariance analysis using SPSS version 22 software.

The results of the present study showed that in the aerobic training group, compared to the control group, the level of ALT and AST decreased significantly (P<0.05). In the aerobic training group, the level of HDL showed a significant increase compared to the control group (P<0.05). Also, the amount of triglyceride, cholesterol, and LDL in the aerobic training group was significantly reduced compared to the control group (P<0.05).

It seems that doing aerobic exercises plays a significant role in improving or reducing liver diseases in patients with type 2 diabetes, But more studies are needed to reach a single treatment strategy and the most effective way.