Investigating the effect of melatonin and tizanidine on hemodynamic parameters and anxiety in patients undergoing cataract surgery: A doubleblind randomized clinical trial study

Cataract is one of the most common diseases in the world and the most common cause of vision loss and blindness in the world. Stability of hemodynamic symptoms is one of the most important factors during cataract surgery. Therefore, the purpose of this study is to investigate the effect of melatonin and tizanidine on hemodynamic parameters in patients undergoing cataract surgery.

This prospective clinical trial study was conducted on 90 patient's candidates for cataract surgery. Patients into three equal groups; Melatonin, tizanidine and placebo were divided. Hemodynamic parameters were recorded at baseline and every 5 minutes during surgery.

There was no difference in the variables of age, sex, weight between the studied groups. Heart rate, diastolic and systolic blood pressure decreased over time in all three groups. Diastolic blood pressure in the 10th minute of surgery (late surgery) in the tizanidine group was significantly lower than the control group (P<0.05).

The results of this study showed that there is no statistically significant difference between the three groups of tizanidine, melatonin and control in terms of hemodynamic parameters. It is suggested that future studies be conducted with a larger sample size and that hemodynamic parameters be measured during recovery and after surgery.