Cytotoxic and Catalytic Features of New Asymmetric Copper(II) Schiff-Base Complexes

The bidentate Schiff-base ligand, N,N'-bis((E)-3-phenylallylidene)-4-nitro-1,2-phenylenediamine, [L], was synthesized and characterized along with its Cu(II) complexes, CuLX2 (where X = Cl and Br). The characterization involved elemental analysis, 1H NMR, 13C NMR, FT-IR, and UV-Vis spectroscopy, as well as thermal and conductivity studies. The elemental analyses of these complexes were consistent with the stoichiometry of the type CuLX2. The confirmation of their stabilization and their slight electrolytic nature is reinforced by their low molar conductivity. Furthermore, the alterations in both the location and shape of the peaks in the UV-Vis and FT-IR spectra of the complexes, relative to those of the free ligand, serve as additional evidence supporting the formation of Schiff-base complexes. Also, cathodic and anodic shifted in the potential’s peaks of complexes compared to free ligand approve formation of compounds. Catalytic activity of these complexes in the room temperature deoximation using sodium periodate were studied. Obtained aldehydes and ketones as single products in excellent yields confirm catalytic activity of these complexes. Lastly, in vitro cytotoxic features of all samples studied against A549 and HT29 cancer cell lines and the outcomes exhibited excellent cytotoxic potential of synthesized complexes.