Production and Characterization of Antibacterial Effective Nanofiber from TPU-Ag NPs and PLA Designed Using Coaxial Electrospinning for Potential Use in Wound Dressing

In this study, a novel bicomponent nanomaterial has been designed to be used as an antibacterial effective wound dressing for dry wounds. These nanofibers' wound dressing successfully have been produced by coaxial electrospinning method feeding neat polylactic acid into the core and thermoplastic polyurethane-silver nanoparticles into the shell. In addition to examining the antibacterial and cytotoxicity properties of the designed polymeric nanomaterials, physical and chemical characterization studies have been also carried out. It has been determined that the 10% silver nanoparticles doped bicomponent nanomaterial had the thinnest smooth nanofibers with 1127 nm value, the highest hydrophobic behavior with 131° contact angle value, the highest tensile strength with 2.53 MPa value, and the highest flexibility with 66.84% value. In addition, 10% and 5% silver nanoparticles doped bicomponent nanofibers have been indicated to have high cell viability with values of about 90% and 80% respectively. It has been emphasized that these bicomponent electrospun mats, which have been improved for dry wounds can be used as a 100% antibacterial effective wound dressing against escherichia coli, staphylococcus aureus, and pseudomonas aeruginosa if it is renewed every 24 hours.