Thermodynamic Study of Deferiprone Dissolution in Polyethylene Glycol 400 and 2-Propanol Mixture

In the current study, the solubility and density of deferiprone were determined in the polyethylene glycol (PEG) 400 and 2-propanol mixtures at 293.2 – 313.2 K using a shake-flask method before a spectrophotometric method. The results showed that the solubility increases with both PEG 400 mass fraction and temperature increase. The measured data were fitted to some mathematical models including van’t Hoff, MRS, Jouyban-Acree, Jouyban-Acree–van’t Hoff, and the modified Wilson models. The results from the investigation of model accuracy showed that there were only tiny differences between measured data and back-calculated data from solubility values (MRD% <3.5%). Moreover, thermodynamic studies showed that the deferiprone dissolution process was endothermic and entropy-driven, and the main contributor of ΔG° was the enthalpy