Study on diagnostic value of ultrasound combined with mammography in breast cancer with different clinical and pathological features

To assess the diagnostic value of ultrasound (US) combined with mammography in breast cancer with different clinical and pathological features.

Totally 340 female patients with breast cancer were enrolled in this study. All patients underwent color ultrasound and mammography examination and the diagnostic efficiency in breast cancer with different clinical and pathological features was assessed.

The diagnostic sensitivity of ultrasound in breast cancer with different Body Mass Index (BMI), initial symptom, histological grade, and hormone receptor (HR) status was similar. The diagnostic sensitivity of mammography in breast cancer with different histological grade, HR status and Ki-67 positive rate was similar. However, the diagnostic sensitivity of ultrasound and mammography was higher in age ≥50 years, human epidermal growth factor receptor 2 (HER2) positive patients. The diagnostic sensitivity of ultrasound in Ki-67 positive rate >20 was higher than that in Ki-67 positive rate ≤20. The diagnostic sensitivity of mammography was higher in BMI >30 and in the initial symptom with calcification. Moreover, in different molecular subtypes, the diagnostic sensitivity of ultrasound and mammography in HR+HER2+ was the highest, followed by HR-HER2+, HR-HER2- and HR+HER2-. The diagnostic efficiency of ultrasound combined with mammography in different age, BMI, initial symptom, histological grade and HR status was similar. In addition, the diagnostic efficiency of ultrasound combined with mammography was higher than single ultrasound and mammography.

Ultrasound combined with mammography showed high diagnostic efficiency in breast cancer with different clinical and pathological features was high, and is worthy for clinical promotion.