A Systematic Review Study on the Role of Long Non-coding RNAs (lncRNAs) in Mycobacterium tuberculosis

Mycobacterium tuberculosis is the bacterium that causes tuberculosis. In this bacteria, long non-coding RNAs (lncRNA) can positively and negatively alter the expression of various genes through various mechanisms, such as activating transcription factors or binding to DNA targets of the chromatin complex. The  current study's purpose was to review the lncRNAs in M. tuberculosis.  The search was done with the keyword including lncRNAs, lncRNA, Long ncRNA, LincRNAs, Long ncRNA, long noncoding RNA, TB, Pulmonary Tuberculosis, Pulmonary TB, Mycobacterium tuberculosis in Pub Med, Web of Science Direct, Scopus, Scientific Information Databases, and Google scholar between 2000 and 2020. A total of 124 articles were found in PubMed,Science Direct, Scopus, Ovid,  Cochrane, and Google Scholar, of which 20  papers were selected from the databases. In revising the title and abstract, 84 articles were excluded from our study. Finally, 19 articles were included in our study, which included 4444 patients with tuberculosis. All studies were performed in China using the qRT-PCR method. The  present study's results showed an acceptable association between lncRNA and SNP with tuberculosis and M. tuberculosis. Also, these regulatory factors play an essential  role as diagnostic biomarkers and the development of new therapies.