Examination of Glutathione S-Transferase (GST) enzyme levels and some biochemical parameters in coronary artery patients

 Heart diseases stand out as a leading cause of death. Specific enzymes are active eliminators of toxic substances from the body. One of the crucial enzymes in this process is Glutathione S-Transferase (GST). In this study, GST activities were determined in individuals with and without coronary artery, and the relationship between some biochemistry tests and GST activity was examined.

This case-control study was conducted on 54 patients with CAD and 54 people without CAD with matched age and sex as control group. Biochemical parameters were measured on an autoanalyzer, and GST enzyme activity was measured on a spectrophotometer. All parameters were examined statistically in line with the data obtained. Data were analyzed by SPSS v.20. A p-value less than 0.05 was considered statistically significant

Accordingly, while there was a statistically significant difference in the GST enzyme activity and HDL-C levels, there was no statistically significant difference in total cholesterol, triglycerides, LDL-C, urea, creatinine and CRP levels. GST enzyme activity level, total cholesterol, triglycerideç LDL-C and CRP levels were found to be higher in thr patient group than the control group, while HDL-C, urea and creatinine levels were found to be higher in the control group than the patient group (Ps <0.05).  

The results obtained indicate that determining the GST enzyme activity level, in addition to routine cardiac markers for the diagnosis of CAD, is important in the diagnosis of CAD-related conditionsç Also ıt will elucidate the mechanisms that constitute the main cause of these diseases.