The Effect of Hydroalcoholic Extract of banana’s peel (Musa spaientum) on Rena Stone induced by Ethylene Glycol in Female Wistar rats

Banana peel has antioxidant, anti-inflammatory, healing and tissue repair properties, and due to its alkaline properties, it increases citrate and decreases urinary calcium, urea, and blood creatinine.

In this study, the effect of hydroalcoholic extract of banana peel on kidney stone disease induced by ethylene glycol was tested in 42 female Wistar rats in 6 groups in 31 days. Healthy control used only food and water, negative control group rats, used food, water, and 1% ethylene glycol solution. The control group 1, used food, water and solution of banana’s peel at concentrations of 100 mg / kg and 150 mg / kg orally. Experimental 1 used food, water, and 100 kg concentration of banana's skin extract solution with 1% ethylene glycol .Experimental 2 rats, used food , water, solution of banana's peel extract at concentration of 150 mg / kg with 1% ethylene glycol solution.. At the end of, blood of samples were collected for biochemical analysis.

The results showed that creatinine, uric acid, and urea increased in the blood of the negative control group, and for creatinine and urea the difference between negative control and healthy control and experimental control 2 was significant. In the uric acid factor, despite the increase in the negative control, the differences are not significant (P<0.05).

The results show the effectiveness of banana peel extract on kidney stones caused by ethylene glycol by inhibiting calcium oxalate formation pathways due to its antioxidant, anti-inflammatory and antibacterial properties.