Choline Chloride-urea as a Solvent/catalyst for the Synthesis of 2-Aminoimidazopyridines via Strecker Reaction

The three-component Strecker reaction between 2-aminopyridine, aldehyde, and KCN in choline chloride-urea deep eutectic solvent (DES) was used for the synthesis of 2-aminoimidazopyridines. This reaction was carried out in simple conditions, and the reaction yields were very favorable. The use of the choline chloride-urea as an environmentally friendly solvent/catalyst is the main advantage of the presented synthesis method.