The Effect of Six Weeks of Intense Intermittent Exercise and Curcumin on Glucose Levels and BMP-2 Gene Expression in Vascular Smooth Muscle of Diabetic Male Rats

The present study was conducted with the aim of investigating the effect of six weeks of intermittent exercise and curcumin consumption on BMP2 gene expression in the vascular smooth muscle of male Wistar rats. In an experimental trial, 30 male Wistar rats were randomly divided into six groups (5 rats in each group): control, diabetic, healthy intermittent exercise, intermittent exercise diabetes, curcumin diabetes and curcumin exercise diabetes. Diabetes was induced by intraperitoneal injection of streptozotocin poison (50 mg/kg). Intermittent training consisted of 5-12 bouts of intense work (75 to 100% of maximum speed) of 60 seconds with active rest intervals of 75 seconds, six days a week for six weeks. Curcumin was fed to animals by gavage at a dose of 50 mg per kilogram of body weight. After six weeks, unconscious animals and blood samples were collected from their hearts. The data were analyzed using ANOVA statistical test and Benferroni post hoc test. Induction of diabetes increased BMP2 gene expression in vascular smooth muscle of male rats. Intermittent training decreased BMP2 gene expression in vascular smooth muscle of diabetic rats. Six weeks of curcumin consumption reduced the expression of BMP2 gene in vascular smooth muscle of diabetic rats. In general, the results of the present study showed that intermittent exercise and curcumin improve diabetes disorders caused by BMP2 gene expression and calcification and its complications.