Formulation of Insulin containing Niosomes and the effect of their oral administration on blood Glucose in Streptozotocin-induced diabetic rats

Abstract:
Multilamellar vesicles (Noisome) of polyoxyethylene alkyl ether surfactants (Brij 52, 72, 76 and 92) were prepared using classic film hydration method. Vesicle formation ability of the surfactants was assessed in presence or absence of cholesterol. All used surfactants formed vesicles in the absence of cholesterol. Recombinant human insulin was used as a model protein drug to investigate encapsulation efficiency and release characteristics of the vesicles. The amount of insulin released in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) from brij 92 vesicles was lower than the other ones. This vesicles also showed the highest protection of insulin against proteolytic enzymes, pepsin and trypsin. Diabetes was induced by IP injection of streptozotocin (65 mg/kg) in male wistar rats. Animals treated with oral niosome (Brij 52 and 92)-encapsulated insulin (100 IU/kg) showed decreased levels of blood glucose and elevation of serum insulin, which in the case of brij 92 niosomes the hypoglycemic effect was significant (P<0.05).
Language:
Persian
Published:
Journal of Kerman University of Medical Sciences, Volume:12 Issue: 2, 2005
Pages:
119 to 129
https://magiran.com/p272188  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 1,390,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!