Investigation of Aurora Kinase-B gene expression in breast cancer patients

Breast cancer remained the leading cause of cancer-related death among women worldwide. Despite considerable advances in early detection and effective therapy, developing chemoresistance and metastatic spread to distant organs is still a pressing clinical challenge. The present study aims to investigate the role of Aurora-B as a potential oncogene in the progression of breast cancer.

Forty breast tumor samples and paired adjacent non-tumor tissues were collected. RNA was extracted and converted to cDNA according to manufacture protocols. The expression of Aurora-B was assessed using quantitative real-time PCR. The relationship between gene expression and the pathological features of the tumors, and the hormone receptors status of the patient’s tumors were also analyzed.

We found a significant overexpression of the Aurora-B gene in tumor samples compared to adjacent normal tissue (p value < 0.05). Moreover, the overexpression of Aurora-B was more increased in IDC tumors in compare to ILC breast tumors. There was not significant change between pre- and post-menopause periods.

Overexpression of oncogenic Aurora-B is associated with the progression of breast cancer. Aurora-B may represent an emerging therapeutic target in breast cancer treatment.