Bioinformatics study of the role of miRNAs in regulating the expression of genes involved in sexual maturity and reproduction in zebra fish (Danio rerio)
MicroRNAs (miRNAs) have known as crucial regulators of gene expression, influencing various biological processes such as sexual maturation and reproduction. In this study, the bioinformatics tools and techniques were used to investigate the role of miRNAs in regulating the expression of genes (ghrhra, kiss2, dnd, gh1, sox9a, shbg, fshb, stat3, cyp17a1, cyp19a1b, ar, amh, esr2b, rspo1, sox21a) associated with sexual maturity and reproduction in zebrafish (Danio rerio). In this study, by integrating computational predictions with experimental validation data, we identified specific miRNA-gene (dre-miR-429a, dre-miR-92a, dre-miR-200b, dre-miR-96, dre-miR-217, dre-miR-155, dre-miR-26a-5p, dre-miR-737, dre-miR-740, dre-miR-737-5p, dre-miR-93, dre-miR-140-3p, dre- miR-15a, dre-miR-144) regulatory networks implicated in key developmental stages and physiological processes related to sexual maturation and reproduction in zebrafish. The findings shed light on the intricate regulatory mechanisms orchestrated by miRNAs in modulating the expression of genes crucial for reproductive success in zebrafish, providing valuable insights into the molecular basis of reproductive biology in this model organism. This study has the potential to deepen our understanding of the regulatory networks involved in the maturation and sexual reproduction of fish.
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