Comparison of the Effect of Running and Swimming on Some Liver Enzymes of Male Rats Induced by Doxorubicin

Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin.

36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05.

Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes.

Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other.