The Response of Oxidative Stress Indicators to Grape Seed Extract Supplementation and Resistance Training in Bodybuilders

Black grape seed extract (GSE) is a supplement known for its potent antioxidant effects and flavonoid properties that can help prevent or reduce cell damage. This study aimed to examine the impact of grape seed extract supplementation and resistance training on oxidative stress indicators in bodybuilders. The research followed a semi-experimental design, with participants divided into supplement and control groups for blood sampling before and after supplement intake in a double-blind fashion. The study included 24 male bodybuilders aged 15-19 years. Blood samples were collected during fasting sessions to measure antioxidant capacity (TAC), malondialdehyde (MDA), creatine kinase (CK), and lactate dehydrogenase (LDH) levels. Data distribution normality was assessed using Shapiro-Wilk tests. The results revealed that resistance training in bodybuilders led to a significant increase in cell damage markers (CK and LDH) and MDA levels, along with a notable decrease in TAC (P<0.05). However, grape seed extract consumption was found to boost TAC levels. The study suggests that bodybuilding activities can elevate cell damage and oxidative stress indicators, while daily intake of grape seed extract (100 mg) can enhance total antioxidant capacity in male bodybuilders.