The effect of 4-week aerobic training with moderate intensity and niglapsin supplement (combination of black seed oil and honey) on the serum level of IgG and IgM in rats treated with lipopolysaccharide

Due to the prevalence of viral diseases and inflammations of the immune system all over the world and in order to improve and strengthen the function of the immune system, lifestyle should be modified. One of the best methods is the use of herbal supplements along with sports activities which is investigated in this study. To conduct the present experimental research, 25 Wistar male rats were purchased from Razi Serum Center and randomly divided into 5 groups : control- LPS model- exercise, LPS model- supplement, LPS model- exercise, supplement and LPS model. Creating a model on rats was done by injecting LPS at a dose of 100 micrograms/kg intraperitoneally to the model groups received the same amount of placebo. Then the experimental groups performed MIT exercises for 4 weeks and 3 days a week and also received supplements by gavage 5 days a week. Finally, the data were analyzed using one-way analysis of variance and Tukey's post hoc test. The data showed that MIT training alone and in combination with supplements have a significant effect on IgG and IgM antibodies (p<0.05). According to the results, it is recommended to use MIT exercises and niglapsin supplement (combination of black seed and honey) to affect important factors in the immune system.