The effect of saffron hydroalcoholic extract on changes in liver-related biochemical factors following chronic vitamin A intoxication in adult male rats

Saffron has anti-seizure, anti-depressant, anti-inflammatory, anti-tumor and memory improvement drugs. In this study, the effect of saffron hydroalcoholic extract on changes in liver-related biochemical factors following chronic vitamin A intoxication in adult male rats was investigated.

For this purpose, 48 adult male Wistar rats weighing approximately 200±20 g were divided into 6 groups of 8. Control group: did not receive any drug treatment, sham group: received only solvent extract, experimental groups 1: Hydroalcoholic extract of saffron alone received 50 mg / kg for 15 days. Experimental group 2: Vitamin A received 50,000 IU for 15 days. Experimental groups 3 and 4: First, they received 50,000 IU of vitamin A for 15 days and then received saffron hydroalcoholic extract at 50 and 80 mg / kg, respectively, for 21 days. At the end of the experiment, the body weight of the animals was measured. Blood samples were taken from the heart and albumin, bilirubin and total protein levels were measured. The results were analyzed using ANOVA and Tukey test.

The mean body weight in the groups receiving vitamin A and saffron hydroalcoholic extract together and alone did not show a significant change compared to the control and sham groups. Mean serum levels of total protein and albumin in experimental group 2 receiving vitamin A and experimental group 3 showed a significant decrease compared to control and control groups. The mean serum levels of total protein and albumin in experimental group 4 showed a significant increase compared to experimental group 2 receiving vitamin A. The mean serum level of total bilirubin in experimental group 2 receiving vitamin A and experimental group 3 showed a significant increase compared to the control and sham groups. The mean serum level of total bilirubin in experimental group 4 showed a significant decrease compared to experimental group 2 receiving vitamin A (P> 0.05).

Saffron hydroalcoholic extract has a protective effect on changes in liver-related biochemical factors following chronic vitamin A poisoning in adult male rats.