Impact of Maternal Separation on Long-Term Potentiation and Synaptic Plasticity: Insights from Rodent Models

Author(s):

Fateme Pishgooei , Saeed Mehrazin , Khadijeh Esmaeilpour*

Message:
Article Type:
Review Article (دارای رتبه معتبر)
Abstract:

Maternal separation (MS) is a well-characterized model of early life stress, based on the postnatal disruption of the mother-infant interaction. Studies on rodents have demonstrated that MS, as an early adverse life event, leads to spatial memory deficits and lasting changes in brain plasticity. Here, we review data from animal studies regarding the impact of MS on long-term potentiation (LTP). Evidence shows that animal models are useful for evaluating the effects of MS on LTP. Overall, studies suggest that MS impairs LTP.

Keywords:

Maternal Separation , Long-Term Potentiation , LTP , MS , Synaptic Plasticity , Brain , Hippocampal Granule Cells , Memory , BDNF , NMDA

Language:
English
Published:
Journal of Pathobiology Reaearch, Volume:25 Issue: 3, Summer 2022
Pages:
36 to 39
https://magiran.com/p2745639