Radiographic evaluation of the effect of domperidone on gastro-intestinal transit time of contrast media in dog

The purpose of the present research was to evaluate the radiographic effect of domperidone on the time of passage of the contrast media through the dog's digestive tract. This study was conducted on 15 healthy dogs and in 3 equal groups. The first group received only ketamine and acepromazine drugs, before administration of contrast media. The second and third groups received domperidone with dosages (0.1 and 0.5 mg/kg) respectively. Then radiography followed at times zero, 20, 40 and 60 minutes and every one hour until the contrast media reaches the colon. Examining the time of contrast media emptying from the stomach showed that there was difference between the domperidone (0.5 mg/kg) group and the groups domperidone 0.1 and control had a significant difference (P<0.05). The average time of complete gastric emptying of the contrast media in dogs of control group, domperidone groups (0.1 and 0.5 mg/kg) were 96±32.86, 52±10.95 and 48±10.95 minutes, respectively. Significant difference was observed between the control group and the other two groups (P<0.05). The average time for the contrast to reach the colon in dogs of the control group, domperidone groups (0.1 and 0.5 mg/kg), 10.2±7.73, 8.2±8.84 and 4.4±1.34 hours, respectively. A significant difference was seen between the domperidone (0.5 mg/kg) group against domperidone (0.1) groups and control (P<0.05). The results showed that the administration of domperidone compared to the control group in both dosage caused complete emptying of the contrast media from the stomach and decreased the time of the contrast media reaching to colon.