The relationship between some SLC30A8 gene polymorphisms and fasting blood sugar and HOMA-IR in patients with type 2 diabetes in an Iranian population in the east of Mazandaran province

Several studies have reported the role of genetic polymorphisms in the onset and development of type 2 diabetes. SLC30A8 is one of the loci containing polymorphism that is associated with the risk of type 2 diabetes. This gene encodes zinc transporter (ZnT8). In this research, the relationship of some polymorphisms of this gene with fasting blood sugar level and HOMA-IR in patients with type 2 diabetes in a population from the east of Mazandaran province was investigated.

133 patients with type 2 diabetes and 128 controls were evaluated in this study. Insulin and fasting blood glucose levels were used to determine HOMA-IR. RFLP-PCR was used to identify rs13266634 and rs11558471 polymorphisms.

The results showed that for rs11558471 polymorphism, both fasting glucose and HOMA-IR were higher in GA+AA group compared to GG homozygotes (p<0.001). Also, for rs13266634 polymorphism, both fasting glucose and HOMA-IR were higher in CT+CC group compared to TT homozygotes (p<0.001).

The results of this study showed that rs13266634 and rs11558471 polymorphisms are related to blood sugar characteristics in this Iranian population with type 2 diabetes. This association may be useful for identifying individuals at high risk of developing type 2 diabetes. Of course, to better understand this relationship, it is necessary to study these polymorphisms in other populations with a larger sample size.