Clinical Manifestations, Histopathological Findings, and Evaluation of Response to Treatment in Parathyroidectomy Specimens in Hospitals of Babol City

Primary hyperparathyroidism leads to increased secretion of parathyroid hormone and hypercalcemia. Parathyroid lesions are often in the form of adenoma, hyperplasia, and carcinoma. The aim of this study was to investigate clinical manifestations, pathological findings, and the response to the treatment in the patients with parathyroidectomy.

In this cross-sectional-analytical study (2002-2017),we extracted data from 37 records  of the patients who had undergone parathyroidectomy in the hospitals associated with Babol University of Medical Sciences. The data were about age, gender, pre-and post-operative values of laboratory indices, pathology of the lesions, and the surgical procedure. Using SPSS- 20 software, data were analyzed by, descriptive statistics, Fisher's exact and Wilcoxon's statistical tests (P<0.05).

The majority of patients were female (67.57 %) and the mean age was 47.13 ± 15.27 years. The disease with skeletal manifestations was more common (45.28%). Adenoma was the most common type of lesion in radiology (78.37 %) and pathology (63.41 %) and the predominant surgical method was unilateral exploration (64.86%). A statistically significant relationship was observed between the type of pathological lesion and the patient's age grou (p=0.037) and gender(p = 0.013). The success of parathyroidectomy surgery was evaluated as significant based on the pre- and post-operative values of calcium (P<0.001) and parathormone (P<0.001).

Primary hyperparathyroidism disease in Iran is a symptomatic disorder that most frequently manifests with bone symptoms, and parathyroidectomy surgery is the definitive treatment method. Improvement of bone symptoms, measurement of calcium, and parathormone can be considered indicators of improvement in these patients.