Clinical and laboratory evaluation in 17 cases of macroprolactinemia identified by polyethylene glycol precipitation test

Macroprolactinemia in which most circulating PRL forms Big Big PRL (>150KD), is a major causes of Idiopathic Hyperprolactinemia with mild or lack of symptoms. We aimed in this study to introduce a simple and inexpensive polyethylene Glycol precipitation test (PEG)for macroprolactin evaluation and avoiding other expensive diagnostic investigations also evaluation of classic hyperprolactinemia symptoms in macroprolactinemic patients In this descriptive study, serum prolactin was measured before and after precipitation of macroprolactin by polyethylene glycole in 90 patients with hyperprolactinemia (PRL>30µg/L), furthermore clinical and radiographic findings recorded. 18.8% of cases were macroprolactinemic without hyperprolactinemic classic symptom. Regarding to high prevalence of macroprolactinemia and lack of classic symptoms of hyperprolactinemia and to avoid diagnostic and trapeutic pitfalls the screening for macroprolactin in all hyperprolactinmia recommended.