Evaluation of Ovarian Reserve with Clomiphene Citrate Challenge Test (CCCT)

Anovulation, as irregular menstrual cycle, causes 40% of infertility. Determining of the response to ovulation induction in these patients appears to be important at the beginning of the treatment. The aim of this study was to evaluate ovarian reserve with clomiphene citrate challenge test. This descriptive study was performed in the year 2003, on 56 infertile women less than 40 years old who were candidate for micro injection in Infertility Center in Babol. Baseline FSH on day 3 of cycle was measured. They were given 100 mg of oral clomiphene citrate on days 5-9 of their cycles, and FSH on day 10 of cycle was measured again. A long protocol was used for ovulation induction in all patients. FSH on day 3 plus FSH on day 10 of cycle less than 26 miu/ml was considered as normal CCCT. Data was analyzed by t-test and fisher exact test and p<0.05 was considered significant. In this study, mean age of patients was 31.1±9.1 years old. From 56 cases, forty nine had normal CCCT, and 38 of 49 cases had suitable ovarian reserve. seven cases had abnormal CCCT and five of them had suitable ovarian reserve. The mean of CCCT result was 15.5±9.1mIu/ml. The most cases who had normal CCCT and suitable ovarian reserve were less than 35 years old. But there were no significant differences between normal and abnormal CCCT groups in women less than or above 35 years. Also, there were no significant differeces between two groups in folicle number, fertilized oocyte and number of emberyos transferred. In evaluation of ovarian reserve not only ccct results, but also age, basal FSH level and anteral follicullar number mast be considered.