Comparative study of CBC, CRP and coagulation factors as the possible risk factors of cardio vascular diseases in patients with gingivitis in comparison with the control group

Patients with periodontitis have more risk factors for cardio – vascular diseases in comparison with healthy people. Considering higher prevalence of cardio–vascular and gingival inflammatory diseases in the society, the present study was carried out to evaluate the means of CBC, CRP, and coagulation factors as possible risk factors of cardio- vascular diseases in patients with gingivitis. Methods & Materials: In this case – control retrospective study, 40 male patients (20-25 years old) referred to Isfahan Dental School, who were selected by non-randomized sample method, were divided into 2 groups: group 1: gingivitis cases & group 2: controls (healthy gingiva). The patients underwent clinical examinations and their bleeding index (CBI) was recorded. Blood sampling was carried out in the patients meeting the study criteria and VII – factor were investigated. Data were analyzed statistically by t-test and ANOVA. RBC was 5.31×106 and 5.08×106 in case and control samples, WBC was 6.35×103 and 6.16×103 in cases and controls and HB was 13.52 and 13.93 gr/dlit in case and control groups. Hematocryte, CRP, fibrinogen and VII factor were respectively 42.72%, 2.05, 215.3 and 176 in cases and 43.07%, 2.04, 183.5 and 181 mg/dlit in controls. No significant differences were found between two groups in these factors. The results showed no significant differences between the patients having gingivitis and healthy gingival, but due to a strong probability for the bacteria and their products to enter the blood in gingivitis and aggravating atherosclerosis, it is recommended to inform the patients and society about these risk factors.