Chromosomal abnormality and genetics factors in recurrent pregnancy loss

Pregnancy loss is a common problem in reproductive–aged women. Although most cases of pregnancy loss are sporadic, some couples experience recurrent pregnancy loss. A variety of possible etiologies have been described for recurrent pregnancy loss. In most cases, the cause is not apparent and often requires intensive and expensive clinical and laboratory investigations, despite which there is still a limited understanding of it. This review focuses on the genetic abnormalities that may contribute to this clinical problem and delineates strategies for genetic evaluation and clinical management in subsequent pregnancies.