Prevalence of Human Papilloma Virus among Women with Cervical Intraepithelial Neoplasia III and Invasive Cervical Cancer from 2001 to 2006 in Bandarabas

To estimate the risk of human papilloma virus (HPV) infection for cervical malignancies, we conducted a case-control study in southern Iran (Hormozgan province). For this purpose, 52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of cervical tissue specimens with normal histopathology as the control group were tested for the presence of HPV DNA using PCR based assay. HPV DNA was found out in 16 out of 52 patients (30.7%), while it was not detected in any of the control group samples. Considering the fact that unrestrained sexual behavior increases risk of becoming infected with HPV, our finding is in favor of the concept of low frequency of HPV infection and thus its less important role in women with cervical cancer in islamic countries.