Investigation of paraquat herbicide on testis histology, fertility, spermatogenesis and pituitary gonad hormones axis in Balb/C mice.

In this investigation the effect of paraquat in concentrations 10, 15 and 20 mg/ kg b.w. have Been worked out in spematogenesis of Balb/C mice. The male mice from 9-10 weeks old age received above mentiond paraquat for two weeks intraperitoneally. The studied variables were the body weight,weight of testis, volume of testis,cell counting inside seminiferous tubules including sertoli cells, spermatogonia, primary spermatocytes, spermatids, sperm and Leydig cells, hormonal assay and fertility.The results of this study showed no significant effect on the body weight and weight of testis. Furthermore, a significant decreasing FSH level was detected in animals treated with paraquat. Also fertility was decreased in treated groups. It is suggested that paraquat may decrease cells kinds into seminiferous tubules in Balb/C mice in male repoductive system and its may decrease fertility ability.