Wound Healing In Castrated Rat

Abstract:
The effect of testosterone on growth, cell proliferation and differentiation have already been shown, but less is reported about it's effect on wound healing. The aim of this study was to investigate the effect of castration on wound healing in animal.Male albino rats weighting 230-280 gr were used. Animals were divided into 4 groups, of: control, sham, castrated and treatment. Rats were anaesthetized by nesdonal (50 mg/kg,ip) and full-thickness skin wounds were made on the back of animals. In experimental group skin wound was performed one week after recovery from castration. Wound healing was evaluated by measuring the wound length, percentage of healing, tensile strength of skin and duration of healing. Results obtained in this study showed that the duration of wound healing was increased in castrated rats compared to control group and the percentage of wound healing was decreased in this group. There was no statistically significant difference between the tensile strength of the control and experimental groups. Duration of healing was decreased in the animals treated by testosterone.Based on the results of this study, we can conclude that because of the delimination of testosterone due to castration, wound healing was impaired and with the presence of testosterone wound healing was accelerated.
Language:
Persian
Published:
Journal of Pathobiology Reaearch, Volume:1 Issue: 3, 1999
Page:
167
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