Effect of central injection of Oxyntomodulin on GLP-1R expression in the brainstem of chicks

Glucagon-like peptid-1 (GLP-1) and Oxyntomodulin are potent hormone released fro gut and have important actions on peripheral tissues and CNS including appetite control. GLP-1 nerve fibers and terminals are widely distributed throughout the brain, with the highest density occurring in the hypothalamus, thalamus and septal regions. The aim of the present study was to investigate the effect of central oxyntomodulin (OXM) injection on expression of GLP-1R mRNA in the brainstem of chicks. RT-PCR results revealed that expression of GLP-1R mRNA was decreased 30 and 90 min after injection of OXM. The present finding shows a negative regulatory effect of OXM on GLP-1R mRNA expression in the brainstem of chicks.