Comparison of Naproxen-Azithromycin Combination with Piroxicam-Azithromycin Combination in Prevention of Complications after Impacted Third Molar Extraction

According to the large number of surgical removal of impacted third molar and prevalence of pain and side effects and importance of prevention to reduce these side effects and also presence of existing studies which show positive effects of prophylactic use of NSAIDs and antibiotics on healing after surgical removal of teeth and periodontal surgery the present study was done to evaluate the effect of NSAIDs and antibiotics on pain and side effects after surgical removal of impacted third molar on patients referred to surgical Department of Tehran Azad university and two private surgical clinics in Tehran in 2008-2009. In this double-blind clinical trial study approved by ethical committee of Azad University of Medical Sciences 31 patients at the age of 17-27 who were candidate for bilateral impacted third molar extraction with the same difficulty index were recruited. Effects of naproxen-azithromycin combination (case side) and piroxicam-azithromycin combination (control side) were evaluated on pain edema dry socket infection and trismus in different times. Data were analyzed with "Mann Whitney" and "Student t-tests". From 60 evaluated samples 24 were from maxilla and 36 were from mandible. Intensity of pain in study groups was lower in control group than the case group (P)