Study of the Correlation between Acetaminophen Consumption and CSF Glucose in Febrile Convulsion

Hyperglycemia and hyperglycorrha ch ia are common associations of febrile seizures. Rapid release of cortisol and adrenaline after seizures as a stress reaction induces elevated glucose concentration. During fever release of interleukin-1 beta, an endogenous pyrogenic cytokine, inhibits insulin release and stimulates the secretion of cortisol. This may explain the correlation between CSF glucose concentration and body temperature in the present report. The purpose of our study was to assess the correlation between acetaminophen consumption and CSF glucose in febrile convulsion. Patients and In this cross-sectional analytic study, we analyzed CSF samples taken from 63 children with febrile convulsion whose ages ranged from 3 to18 months. Comaprisons between the mean CSF glucose concentrations in the children who had taken and not taken acetaminophen within 6 hours before convulsion were made using Student's t-test and Mann-whitney test. CSF glucose levels were significantly higher (P =0.. 0001) in children who had not taken acetaminophen (82±8 mg/dL, n =) as compared with children who had taken acetaminophen (53±4 mg/dL, n=). The use of acetaminophen decreases CSF glucose concentration in febrile convulsive children.