The comparison of propofol and nesdonal on succinylcholine-induced fasciculations, myalgia and postoperative sore throat

The purpose of this study is to determine the effects of propofol and nesdonal on the incidence rate of postoperative fasciculation, myalgia and sore throat after succinylcholine administration. In a prospective randomized double-blind study, 100 patients who were in ASA class I, II (between 20-60 years old) allocated into two equal groups (I, II). In group I and II propofol (2 mg/kg) and nesdonal (5 mg/kg) were used for induction, respectively. In both groups succinylcholine (1 mg/kg) had administrated for orotracheal intubation. Fasciculation after administration of succinylcholine, and myalgia and sore throat 24 hours after operation were observed. In the patients who received propofol (Group I), 8 patients had not any fasciculation (16%) and in the other 42 patients (84%) the occurred fasciculation was not severe. In the patients who received nesdonal (Group II), only 2 patients had not any fasciculation (4%) and 48 patients had fasciculation (96%). Incidence rate and severity rate of fasciculation in group II were significantly more than group I (P=0.046). Sore throat in group I was seen in 34 patients (68%) and in group II was seen in 46 patients (92%). There is a significant deference between two groups (p=0.003). Myalgia also was reported in 30 patients (60%) of group I and in 40 patients (80%) of group II (P=0.029). Using propofol versus nesdonal can reduce the succinylcholine-induced fasciculation, myalgia and postoperative sore throat.