INDOMETHACIN THERAPY IN SEVERE POLYHYDRAMNIOS

Polyhydramnios is defined as excessive accumulation of amniotic fluid. It is associated with inceased incidence of abruptio placenta, preterm birth, cord prolopse and neonatal death (30%). So in this clinical trial, 12 pregnant women with significant polyhydramnios (AFI> 24 cm) and gestational age of 24-32 weeks, received oral Indomethacin at a dose of 100 mg/day for 8 days. AF volume decreased in all patients (P=0.000). We didn’t observe any maternal and fetal-neonatal side effect due to indomethacin therapy. Mean gestational age at delivery was 37.7 ± 1 weeks. It can be concluded that short term indomethacin therapy is effective in significant polyhydramnios without any maternal and fetal side effect.