Helicobacter pylori Antibody titer in Migraine patients in Ilam

Migraine is the most common headache in different communities and approximately 12-15% of individuals are suffering worldwide. Recent studies have revealed a relationship between Helicobacter pylori infection and migraine. The aim of presend study was to evaluate the antibody titer against H.pylori in patients with migraine and comparison to healthy subjects. This case – control randomized study was carried out in patients whose migraine has already been diagnosed referred to University neurology clinic and private medical sectors in Ilam, Iran.Seventy migraine patients as the case group and 70 healthy individuals as control group were participated in this study. The demographic criteria of both groups were identical. Blood samples were taken from all subjects and was used for evaluation of IgG antibody titer against H.pylori by using ELISA method. The mean antibody titer were compared in both groups. Household women had the highest prevalence of migraine (40%), which showed a correlation with menstruation in 21 women (45.7%). Fifty three patients with migraine (75.7%) had gastrointestinal disorders, which in 48 patients (68.6%), this was in correlation with certain nutritional habits. Stress was reported as the most important cause of migraine in 15 patients (21.4%) that in 91.4% of them, headache wasfollowed by anxiety. In 51 patients (72.9%), sleep disorder was seen. The mean OD value of antibody titre against H.pylori was 60.08 in case group and 21.82 in control group, which the difference was significant (P<0.05). The significant difference for the mean OD value to H.pylori among case and control groups in present study, shows the importance of investigation of H. pylori infection in patients with classic migraine,which needs more complementary tests. It is suggested that treatment of H.pylori infection may affect the disease and probably cure the headache partially.