Effects of Oxybutynin and Detrusitol on Urinary Dysfunction of MS Patients

Multiple Sclerosis (MS) is a chronic disease of high prevalence of central nervous system, mostly affecting young adualts especially females. Voiding dysfunction is one of its complications, diagnosis and treatment of which will be of great value in patients, quality of life. In this study, frequency and type of urinary dysfunction in MS were evaluated and effects and side effects of two drugs of Oxybutynin and Detrusitol were compared.This clinical trial study was performed from July 2004 until July 2005 at Ghaem Hospital of Mashhad University of Medical Sciences on women with clinical manifestations of voiding dysfunction (overactive bladder). Patients were divided into two groups randomly. One group treated with Oxybutynin 5 mg bid, and the other with Detrusitol 2 mg bid, and effects and side effecto of these drugs were compared. Data analyzed using χ2, fisher T-student andcochrane tests.The ratio of female to male was 6 to 1. The average age of onset was 25.8. Spastic urinary dysfunction prevalence was 61.2%. The most common symptom was urination frequency. Improvement in urinary symptoms were similar in both groups. Among observed side effects, only dry mouth was statistically more frequent in patients who used Oxybutynin in comparison to those who used Detrusitol. Patients satisfaction was similar in both groups. There was a relationship between existence of plaques in periventricular white matter and urinary dysfunction symptoms.According to the rate of improvement, side effects and the costs, Oxybutynin is more suitable for overactive bladder treatment.