Association of M55V Polymorphism of Sumo4 with Type 2

Sumo4 has recently been found to be mainly expressed in kidney. Single nucleotide polymorphism, which is detected in sumo4, replaces a highly conserved methionine with a valine (M55V) residue. This variant of sumo4 may induce higher nuclear factor–KB (NFKB) activity because NFKB is known to mediate the development of diabetic nephropathy. Patients and This study involved 50 patients with type 2 diabetes and 50 healthy subjects.The M55V polymorphism of sumo4 was genotyped by PCR and restriction enzyme digestion. The serum glucose concentration was measured by enzymatic method. Student's t-test and Chi-square test were used to analyze the data. The frequency of sumo4 AA, GA and GG was 20%, 44% and 36% in the case group and 26%, 50% and 24% in the control group respectively. The results suggest that the sumo4 M55V variant is not associated with type 2 diabetes mellitus susceptibility, suggesting that it may not be involved in the pathogenesis of type 2 diabetes.