IFN-γ +874 and IL-4 -590 Polymorphisms and Asthma Susceptibility in North West of Iran
Author(s):
Abstract:
Background
Recent studies have documented an association between some cytokines’ gene polymorphisms and chronic inflammation of the respiratory tract which leads to asthma susceptibility. This study was conducted to investigate if there were any differences in IFN-γ +874 (A/T) and IL-4 -590 (C/T) single nucleotide variations in asthmatic patients compared to normal controls among West Azerbaijani population.Materials And Methods
IFN-γ +874 (A/T) and IL-4 -590 (C/T) polymorphisms were amplified by ASO-PCR and RFLP-PCR from genomic DNA of 173 individuals including 64 asthmatic patients and 109 control subjects from West Azerbaijani population.Results
The allele or genotype frequencies of IFN-γ +874 A/T in patients were not different from those of controls (p>0.05). The differences between allelic or genotypic frequencies of IL-4 -590 C/T in patients and controls were not statistically significant (p>0.05).Conclusion
These findings showed that IL-4 -590 (C/T) and IFN-γ +874 (A/T) polymorphisms were not associated with asthma susceptibility.Language:
English
Published:
Tanaffos Respiration Journal, Volume:9 Issue: 4, Autumn 2010
Page:
22
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