Effects of total extract and its different hydromethanol fractions of Iranian black tea on inflammatory factors and glycosilated hemoglobin (HbA1c) in STZ-induced diabetic rats

Reliable findings indicate that inflammatory factors and glycosilated hemoglubin (HbA1c) disorders has the main role in pathogeneses of diabetes and its complications. Traditionally plant extracts have been used for diabetes control. This study was aimed to examine the effect of total and different fractions of black tea on inflammatory factors and glycosilated hemoglobin (HbA1c) in diabetic rats. This study was conducted on 56 rats which were randomly divided into 8 groups (7 rats in each group)and they were studied for one month. The weight of rats was 200 – 250 gr. Groups 1 and 2 were non-diabetic, groups 3–8 were diabetic, and diabetes was induced by intraperitoneal injection of streptozotocin 60mg/kg. Groups 1 to 8 were received by intraperitoneal injection: vehicle, total extrac (50mg/kgw), vehicle, total extrac (50mg/kgw)t, methanol fractions of 20%, 40%, 60%, 80% plus 100% respectively. In the end of study blood samples were taken from all groups and glycosilated hemoglobin (HbA1c) and inflammatory factors: Interleukin-1,6, TNFα and CRP were measured. In this study concluded that injection of total extract and 20% fraction of black tea had decreased inflammatory factors in diabetic and non diabetic rats (p<0.05). but did not on glycosilated hemoglobin (HbA1c). It can be concluded that injection of total extract and 20% fraction of black tea had positive effect on inflammatory factors in diabetic rats