Detection of H. pylori infection and cagA strains seropositivity in adult dyspeptic patients in east Azerbaijan, northwest of Iran

Helicobacter pylori (H. Pylori) bacteria colonize human stomach mucosa and may establish acute or chronic gastric inflammation. Cytotoxic–associated gene A (cag A) is associated with higher grades of gastric inflammation and carcinoma. In the present study we determine cag A seropositive strain in dyspeptic patients with H. pylori infection.Patients and Six hundred adult dyspeptic patients examined for anti H. Pylori and anti-cag A antibodies by enzyme–linked immunoassay (ELISA) method. All cases resided in east Azarbijan in northwest of Iran and were enrolled in a 5–year period (2003–2008). A total of 85.5% of dyspeptic patients were positive for H. pylori infection. Anti–cag A antibody was detected in 35.6% of patients with H. pylori infection. Screening of H. pylori infection by ELISA method revealed that the vast majority of (85.5%) dyspeptic patients are seropositive for H. pylori. Determining of photogenic strains of H. pylori by anti–cag A antibody could be diagnostic in severe gastric infections.