Does Traumatic Uncontrolled Blood Loss Require Intensive Hydration Therapy?

Hemorrhage in trauma is important and replacement of the blood loss is one of the ways which may reduce the number of mortalities. We decided to study the use of hypersaline serum in comparison with normal saline serum and not prescribing blowing serum in caring animal simulation model of uncontrolled hemorrhagic shock following trauma. The assessment of 3% hyper saline serum application compared with saline normal serum and not prescribing blowing serum in caring animal simulation model of hemorrhagic shock in trauma. The animal lab investigation and the grant of this animal trial was provided by AJA University of medical science. The goats were sedated with Ketamine and Diazepam. The tracheostomy was done on the goat and was ventilated with portable ventilator. Continuous blood pressure and electrocardiogram monitoring was positioned. Animals were cut and blood volume was measured. The bleeding was not being controlled and after 300-350 ml of bleeding, the goats were randomized into 3 groups; those treated with normal saline 20ml/kg (n=10), hypersaline 3% 6ml/kg (n=10) and no fluid resuscitation (n=10). Data related to the duration of survival, volume of lost blood, blood pressure and metabolic acidosis were gathered and analyzed. Blood volume loss in normal saline group, hypersaline group and no volume resuscitation group was 1139ml, 1551ml, 600ml respectively. The mortality rate significantly increased using hypersaline. Also, blood acidosis increased and hemoglobin decreased significantly while using normal and hypersaline serum vs. no fluid resuscitation.Discussion and Resuscitation with normal saline or hypersaline can increase blood loss during a hemorrhagic shock and do not improve survival.