The Therapeutic Effect of Colchicine on Delayed Pulmonary Injury of Sulfur Mustard in Animal Model

Among late complications of sulfur mustard gas, respiratory problems, especially chronic bronchitis and pulmonary fibrosis, are the greatest causes of long-term disability. Colchicine has anti-inflammatory effects and also indication of its usage in pulmonary fibrosis. According to these and note to the effect of oxidative stress in pathogenesis of chronic bronchitis and pulmonary fibrosis, the therapeutic effects of Cochicine and the role of oxidative stress in its mechanism was studied.

One group of mice that had inhaled sulfur mustard one month ego was treated by colchicine. After sacrificing and sampling, biochemical indeces of chronic inflammation and pulmonary fibrosis of experimental group was compared with positive and negative control groups.

A significant decrease was seen in alveolar space percentage, serum vitamin C, and catalase and an increase was seen in hydroxylproline concentration, lymphocyte infiltration, and serum H2O2 in positive control group in comparison with negative control. Vitamin C and catalase increase and hydroxylproline concentration, lymphocyte infiltration and serum H2O2 decrease in experimental group in comparison with positive control group were obtained.

Colchicine has therapeutic effects on delayed lung complications of sulfur mustard gas injury and diminishing the oxidative stress can be one of mechanisms of this drugs.