Effect of 12 Weeks Life-Style Activity Modification on Serum Oxidized LDL-C in Obese Men

Exercise significantly prevents the progression of atherosclerosis and oxidized LDL-C (ox-LDL-C), facilitates monocyte-related atherogenesis. The effects of Lifestyle Activity Modification (LAM) training based on guidelines of the Centers for Disease Control (CDC) and the American College of Sports Medicine (ACSM) on serum oxidized LDL-C (ox-LDL-C) in obese people are not well known. We investigated the effect of LAM on serum ox-LDL-C in obese middle aged men. Sixteen healthy obese middle aged men (aged 42.06±6.01 years, mean ± SD) were randomly assigned to the LAM (n=8) and the control (n=8) groups. Subjects in the LAM group walked 2 miles daily in 30 minutes 4 days weekly for 12 weeks on treadmills, according to the CDC and ACSM guidelines. Results showed that body weight, BMI, body fat mass, body fat percent, waist to hip ratio (WHR) and LDL-C decreased significantly after 12 weeks in the LAM group compared to the controls (P<0.05), and their maximum oxygen uptake was increased significantly compared to the controls after 12 weeks (P<0.05). On the other hand, after 12 weeks of LAM training, no significant differences were observed in serum ox-LDL-C, total cholesterol (TC), triglycerides (TG) and HDL-C between the groups. Although twelve weeks of LAM improved body composition and cardio-respiratory fitness and decreased LDL-C levels in obese middle aged men, serum ox-LDL-C were not affected by this protocol in this group.