The Association of Vitamin D and Glycemic Profiles in Diabetic Patients Compared to Healthy Control

Vitamin D deficiency is a prevalent disorder in the world particularly in Asian countries including Iran. There are increasing evidences about the relationship between serum level 25 hydroxy vitamin D [25(OH)D] and the control of diabetes. In this study, we aimed to determine the relationship between serum level of 25(OH)D and glycemic profile in patients with type 2 diabetes mellitus (DM) in compared to healthy subjects. This cross-sectional study was conducted on 180 people. 95 patients with type 2 DM were randomly selected among members of Iranian Diabetes Association (patients group). 85 healthy subjects were matched with patients group according their age and gender (control group). Biochemical parameters including 25(OH)D, calcium, phosphorous, parathormone (PTH), glucose, HbA1c, insulin were measured. Homeostasis model of assessment- insulin resistance (HOMA-IR) index was calculated. 82% of patients group and 75.6% of healthy subjects were suffering from vitamin D deficiency or insufficiency. There is an significant inverse relationship between 25(OH)D and glycemic profile except insulin concentration (FBS and HbA1c). We concluded that vitamin D deficiency has high prevalence among type 2 diabetic patients and also healthy subjects. Vitamin D has an inverse relationship with glycemic control in type 2 diabetic patients.